![]() ![]() Tissue fragments, to be differentiated from groups, clumps or clusters that often result from centrifugation and other concentration artifacts, were strongly associated with urothelial neoplasia, uncommonly with nonneoplastic disease processes affecting the urinary tract but always with urothelial disease. The results of the present investigation using the Millipore filter technique for voided urine cytology processing, differed from those of a recently published study that employed cytocentrifugation. Proper identification of tissue fragments was highly significant and correlated with urothelial neoplastic changes. Beets, blackberries and rhubarb can turn urine red or pink. Hard exercise, such as long-distance running, also can cause this bleeding. Some cancers can cause blood in urine too. The specificity of cytology is greater than 90, while the sensitivity for high-grade disease and carcinoma-in-situ (CIS) can be as high as 80 to 90 6, 7. Three-dimensional groups were also statistically more common in cases with invasive transitional cell carcinoma. Health problems that can cause blood in the urine include an enlarged prostate, tumors that arent cancer, and kidney stones and cysts. Urinary cytology identifies malignant cells that have been exfoliated from the urothelium into the urine. 005) in urine specimens with biopsies revealing urothelial malignancies than in negative biopsies (6%). Cell groups (tissue fragments) consisting of either flat sheets or three-dimensional structures were significantly more common (57%) (chi 2 P <. 28, 29 However, if true papillary fragments are seen in a specimen (thus indicating the presence of a papillary neoplasm) and features of HGUC are absent, TPS allows for a diagnosis of LGUN to be made. Of the 2,553 voided urine specimens examined, 174 (7%) had corresponding biopsies. One such instance includes the presence of benign-appearing urothelial tissue fragments in a voided urine specimen. Doctors call blood in the urine haematuria (pronounced heem-at-you-ree-ah). The type and number of tissue fragments were correlated with the histologic diagnosis and clinical features the results were compared to those from a recently published study. Hematuria (blood in the urine) Nocturia (frequent urination at night) Pyuria (unusually high amount of white blood cells in urine) Severe pain on. We reviewed all the voided urine specimens collected and processed by the Millipore filter technique (Bedford, Massachusetts, U.S.A.) at our institution between January 1, 1997, and December 31, 1998, and the corresponding biopsies obtained within 120 days after urine examination. Dysuria (painful urination) Fever and chills. To determine the diagnostic significance of tissue fragments in voided urine specimens. Endometriosis and menstrual clots: What to know. Causes Possible causes of white particles, or sediment, in urine include: 1.
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